Colchicine in Familial Mediterranean Fever

Letters and Corrections1 September 1977Colchicine in Familial Mediterranean FeverRIDA A. FRAYHA, M.D.RIDA A. FRAYHA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-87-3-382_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The cause and pathogenesis of familial Mediterranean fever (FMF) are not clear, hence treatment, by necessity, has been empirical. Prophylactic colchicine therapy has recently been shown to be highly effective in preventing the attacks by suppressing the inflammatory reaction and its symptoms without affecting the basic biorhythm or the underlying excitatory process (1, 2). The mechanism of action of colchicine in FMF remains unclear. Colchicine is known to disrupt the intracellular microtubular structures and to interfere with cellular motility and division. Dinarello and associates (3) have recently shown that patients with FMF on colchicine have significantly fewer...References1. GOLDSTEINSCHWABE RA: Prophylactic colchicine therapy in familial Mediterranean fever. A controlled, double-blind study. Ann Intern Med 81:792-794, 1974 LinkGoogle Scholar2. ZEMERREVACHPRAS DMM: A controlled trial of colchicine in preventing attacks of familial Mediterranean fever. N Engl J Med 291:932-934, 1974 CrossrefMedlineGoogle Scholar3. DINARELLOCHUSIDFAUCI CMA: Effects of prophylactic colchicine therapy on leukocyte function in patients with familial Mediterranean fever. Arthritis Rheum 19:618-622, 1976 CrossrefMedlineGoogle Scholar4. KHACHADURIANARMENIAN AH: The management of familial paroxysmal polyserositis. Experience with low-fat diets and Clofibrate. Leb Med J 25:495-502, 1972 MedlineGoogle Scholar5. STEINSTEIN OY: Colchicine-induced inhibition of very low-density lipoprotein release by rat liver in vivo. Biochem Biophys Acta 306:142-147, 1973 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Internal Medicine American University Hospital Beirut Lebanon PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1977Volume 87, Issue 3Page: 382-382KeywordsColchicineFeversPathogenesis Issue Published: 1 September 1977 PDF DownloadLoading ...