细胞毒性
细胞凋亡
化学
部分
肝细胞癌
电喷雾电离
细胞周期检查点
细胞周期
立体化学
肝癌
质谱法
分子生物学
癌症研究
生物化学
生物
体外
色谱法
作者
Jatinder Singh,Dae Won Park,Dong Hwan Kim,Nem Singh,Se Chan Kang,Ki‐Whan Chi
出处
期刊:ACS omega
[American Chemical Society]
日期:2019-06-21
卷期号:4 (6): 10810-10817
被引量:4
标识
DOI:10.1021/acsomega.9b00093
摘要
Ru(II)-metallomacrocycles containing 4-pyridyl-1,2,3-triazole moiety were realized by coordination-driven self-assembly. All new compounds were characterized by electrospray ionisation mass spectrometry, elemental analysis, and 1H and 13C NMR spectroscopic techniques. The molecular structure of metallomacrocycle 8 was determined by single-crystal X-ray crystallography. The anticancer activities of metallomacrocycles 5-8 were evaluated by cytotoxicity, cell cycle analysis, and related protein expression. Metallomacrocycle 7 showed the highest cytotoxicity in HepG2 human hepatocellular carcinoma cells. In addition, apoptotic HepG2 cells were analyzed when metallomacrocycle 7 was treated. Our results suggest that metallomacrocycle 7 induces liver cancer cell death by increasing apoptosis and cell cycle arrest and that it has potential use as an agent for the treatment of human hepatocellular carcinoma.
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