喜树碱
纳米医学
DNA
化学
组合化学
生物结合
水溶液
药品
药物输送
体内
结合
生物物理学
纳米技术
材料科学
纳米颗粒
生物化学
有机化学
药理学
生物
数学分析
生物技术
数学
作者
Jiao Zhang,Yuanyuan Guo,Fei Ding,Gaifang Pan,Xinyuan Zhu,Chuan Zhang
标识
DOI:10.1002/anie.201907380
摘要
Abstract Most chemotherapeutics are hydrophobic molecules and need to be converted into hydrophilic form before administration. Based on the excellent hydrophilicity and programmability of DNA, now, a general strategy to construct a precise drug‐containing DNA framework for cancer treatment is reported. In this novel drug delivery system, carbonethyl bromide‐modified camptothecin (CPT) is employed to directly react with phosphorothioate (PS) modified DNAs, resulting in the formation of chemotherapeutics‐grafted DNAs with a responsive disulfide linkage. By tuning the number and site of PS modifications on DNA strands, hydrophilicity of the obtained DNA‐drug conjugates (DDCs) can be regulated to retain their aqueous solubility and capability of molecular recognition. Subsequently, programmable DNA nanotechnology enables the self‐assembly of a precise drug‐containing tetrahedral framework with stimuli‐responsive feature and enhanced antitumor efficacy both in vitro and in vivo.
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