细菌
革兰氏染色
微生物学
克
荧光
体内
革兰氏阳性菌
生物
革兰氏阴性菌
大肠杆菌
生物技术
生物化学
基因
光学
遗传学
物理
作者
Hyeokjin Kwon,Xiao Liu,Eun Gyeong Choi,Jung Yeol Lee,Seongwook Choi,Junyoung Kim,Lu Wang,Sung-Jin Park,Beomsue Kim,Yong‐An Lee,Jong Jin Kim,Nae Gyu Kang,Young Tae Chang
标识
DOI:10.1002/anie.201902537
摘要
The rapid and sensitive classification of bacteria is the first step of bacterial community research and the treatment of infection. Herein, a fluorescent probe BacGO is presented, which shows the best universal selectivity for Gram-positive bacteria among known probes with a minimum staining procedure for sample detection and enrichment of the live bacteria. BacGO could also be used to assess of the Gram status in the bacterial community from wastewater sludge. Furthermore, BacGO could sensitively and selectively detect a Gram-positive bacterial infection, not only in vitro but also using an in vivo keratitis mouse model. BacGO provides an unprecedented research tool for the study of dynamic bacterial communities and for clinical application.
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