细胞命运测定
基因组
染色质
转录因子
生物
计算生物学
细胞生物学
基因表达调控
抄写(语言学)
进化生物学
遗传学
基因
语言学
哲学
作者
Ralph Stadhouders,Guillaume J. Filion,Thomas Graf
出处
期刊:Nature
[Springer Nature]
日期:2019-05-15
卷期号:569 (7756): 345-354
被引量:362
标识
DOI:10.1038/s41586-019-1182-7
摘要
How cells adopt different identities has long fascinated biologists. Signal transduction in response to environmental cues results in the activation of transcription factors that determine the gene-expression program characteristic of each cell type. Technological advances in the study of 3D chromatin folding are bringing the role of genome conformation in transcriptional regulation to the fore. Characterizing this role of genome architecture has profound implications, not only for differentiation and development but also for diseases including developmental malformations and cancer. Here we review recent studies indicating that the interplay between transcription and genome conformation is a driving force for cell-fate decisions.
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