生育率
内科学
科克伦图书馆
系统回顾
随机对照试验
观察研究
克罗恩病
作者
Antara Banerjee,Marco Scarpa,Surajit Pathak,Patrizia Burra,Giacomo Carlo Sturniolo,Francesco Paolo Russo,Ram Murugesan,Renata D'Incà
出处
期刊:Endocrine‚ Metabolic & Immune Disorders-Drug Targets
日期:2019-01-01
卷期号:19 (7): 959-974
被引量:3
标识
DOI:10.2174/1871530319666190313112110
摘要
Background and aims Sexual functions are sometimes adversely affected by the therapeutic drugs delivered for treating IBD. Much attention has been focused on pregnancy/sexual issues in women. Relatively less attention has been poured in to address this issue in men. This systematic review assesses the drugs having potential detrimental effects on fertility in men. Methods Three databases were searched by two researchers independently for potentially relevant publications between 1964 to 2015 and 249 papers were retrieved. Studies that dealt with sexual problems after IBD drugs administration were included in the purview of this review. Results Fourteen studies with 327 human patients and 110 animals were analysed. Sulphasalazine treated patients had lower spermatozoa count, lower sperm motility and higher risk of oligospermia compared to mesalazine treated ones. Biologics seem to be safe to use while attempting to conceive however, proper clinical studies reporting male fertility problems in IBD patients are lacking. Azathioprine caused oligospermia but a meta-analytical approach was not possible due to heterogeneity in studies. Some animal studies showed methotrexate affects abnormal testis structure and spermatogenesis. Conclusion This study summarises the current literature and safety issues affecting fertility parameters in men and animals treated with IBD therapeutic drugs, which can further assist clinicians in better management of adult male IBD patients.
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