概念证明
医学
细胞
癌症研究
化学
计算机科学
生物化学
操作系统
作者
Marie‐Eve Beaulieu,Toni Jauset,Daniel Massó-Vallés,Sandra Martínez-Martín,Peter B. Rahl,Loïka Maltais,Mariano F. Zacarías Fluck,Sílvia Casacuberta‐Serra,Erika Serrano del Pozo,Christopher Fiore,Laia Foradada,Virginia Castillo Cano,M. Sánchez-Hervás,Matthew G. Guenther,Eduardo Romero,Marta Oteo,Cynthia Tremblay,Génesis Martín-Fernández,Danny Létourneau,Martin Montagne
标识
DOI:10.1126/scitranslmed.aar5012
摘要
We demonstrate the pharmacologic potential of the purified cell-penetrating Omomyc mini-protein to directly inhibit MYC function in vitro and in vivo.
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