Metal-free Synthesis of 2,4,6-Trisubstituted Pyrimidines using α,β.- Unsaturated Ketones and Benzamidine via Tandem Annulation-Oxidation Pathway

A tandem metal-free synthesis of partly and fully substituted pyrimidines has been accomplished from α,β-unsaturated ketones and benzamidine in presence of triethyl amine. The reaction proceeds via [3+3] annulation-oxidation sequence and the protocol has been found successful for the synthesis of a wide range of pyrimidine derivatives. Keywords: Benzamidine, Metal-free synthesis, Triethyl amine, Tandem [3+3] annulation-oxidation pathway, α, β-Unsaturated ketones.