HPV-related Vulvar Disease

Human papillomaviruses (HPV) are the most common cause of sexually transmitted infections worldwide and can play a role in vulvar disease. This review provides a clinically relevant summary of our current understanding of the virology, epidemiology, and pathogenesis of HPV along with diagnosis and management strategies of condyloma acuminata, vulvar intraepithelial neoplasia (VIN), and invasive squamous cell carcinoma. Formal screening and management guidelines for vulvar disease, especially cancer, remain limited, highlighting the need for more robust evidence and consensus. Early recognition, appropriate intervention, integrating close follow-up, and prevention strategies (ie, vaccination) can greatly impact the burden of HPV-associated vulvar diseases.