A “Jack-of-All-Trades” Phototheranostic System Enabled by Strategic Regulation of Ferroptosis and PANoptosis for Cancer Therapy

) reactive oxygen species (ROS), and exhibited super photothermal conversion efficiency of 48.49%, endowing it with a synergistic photodynamic therapy (PDT)-photothermal therapy (PTT) capability to effectively suppressing tumor growth. Mechanistically, the therapeutic effects were mediated primarily through the regulation of ferroptosis and PANoptosis pathways. Overall, this system offers innovative insights for advancing the development of phototheranostic agent and enhancing the understanding of their underlying molecular mechanisms.