The research for serum endostatin level in early diagnosis of lung cancer

Objective To measure the serum levels of endostatin in lung cancer patients in different stages and with histological types,and explore the clinical value of serum level in early diagnosis of lung cancer.Methods ELISA was used to detect the level of serum endostatin in 81 patients with lung cancer(lung cancer group),23 patients with benign lung disease(benign lung disease group),20 healthy controls(healthy control group).The serum levels of endostatin were analyzed in lung cancer patients in different stages and with histological types.Results The serum level of endostatin in lung cancer group was(2.53±8.75)ng/mL,significantly higher than that in benign lung disease group (4.63±1.12)ng/mL and healthy control group(4.53±1.24)ng/mL.In lung cancer group,the serum level of endostatin of stageⅠsubgroup andⅡsubgroup was significantly higher than that of stageⅢsubgroup.The differences were statistically significant.There were statistical differences of serum level of endostatin among the lung cancer patients with different histological types.Conclusion Serum endostatin might be used as an indicator of early diagnosis of lung cancer.