Polymorphism analysis of CYP1A1 MspI in ovarian cancer

Objective To detect the polymorphism of CYP1A1-MspI gene in patients with ovarian cancer.and discuss the relationship between the polymorphism ofCYP1A1-MspI gene and correspond cases' general materials and clinical materials.Methods The free peripheral blood samples of 81 cases confirmed to be ovarian cancer by postoperative pathology were collected preoperatively and the polymorphism of CYP1A1-MspI gene was detected.The clinical materials of the 81 cases with different genotypes were compared.The relationship between the polymorphism and clinical materials was analyzed.Results Among the 81 cases of ovarian cancer,there were 47 cases of wild type-genotype A(T/T)(58%),25 cases of mutation heterozygosis-genotype B(T/C)(31%),and 9 cases of mutation homozygosis-genotype C(C/C)(11%).The genotypic frequency distribution in patients aged from 12 to 29 was one case of genotype A(2.1%),5 cases of genotype B(20.0%),and no case of genotype C.The genotypic frequency distribution in patients aged from 30 to 49 was 12 case of genotype A(25.5%),8 cases of genotype B(32.0%),and 3 cases of genotype C(33.3%).The genotypic frequency distribution in patients aged from 50 to 69 was 31 case of genotype A(66.0%),8 cases of genotype B(32.0%) and 4 cases of genotype C(44.4%).The genotypic frequency distribution in patients aged more than 70 years was 3 case were of genotype A(6.4%),4 cases of genotype B(16.0%),2 case of genotype C(22.2%).There were significant differences of the ages of onset between patients with different CYP1A1-MspI genotypes (P0.05).There were 40 cases of genotype A(85.1%),15 cases of genotype B(60.0%),and 9 cases of genotype C(100%) in epithelial cancer patients.There significant differences of the constituent ratio of the ovarian cancer pathological types between patients with different genotypes(P0.05).Conclusion Polymorphism of CYP1A1-MspI gene exisits in patients with ovarian cancer.The age of onset of patients with ovarian cancer is related with CYP1A1-MSPI genotypes;The incidence of epithelium tumor in patients with genotype A is higher than that of other ones.The ratio of non-epithelial tumor in the patients with mutation allele gene C has an increasing tendency.