Cancer treatment remains a serious problem worldwide. Analysis on the relationship between cancer cells and normal cells has revealed that this two kinds of cells share the characteristics of the two aspects in a contradiction, thus could be analyzed by using contradictory principle. Under the guidance of contradictory principle, induction of a dormant state or reversal of cancer cells are important treatment strategies besides killing them. Normal cells also should be the targets and influences of treatment targeting cancer cells on normal cells should be considered. Findings based on the pathway crosstalks between the two kinds of cells may offer opportunities for the development of new biomarkers and therapies.