Objective:To investigate the changes of t he mean velocity(Vm) by transcranial doppler ultrasound(TCD) in the middle cer ebral artery(MCA) area with acute ischemic stroke patients,and to evaluate the s ignificance of TCD findings in the different course of stroke. Methods:Fourty nine stroke patients,proven by CT and/or MRI scan in the MCA area,got TCD serial examination at 1,2,3 weeks after admission.Results:①The Vm in ipsilateral MCA was significantly lo wer than that of the contralateral(P0.01) and the control group(P0.0 5); and the Vm in bilateral anterior cerebral artery(ACA) in ischemic stroke was significantly higher than that of the control(P0.05).The physiological ph enomenon of MCA VmACA Vm disappeared.②The MCA Vm of the stem and the penetrat ing arteries occlusion in the MCA area reduced significantly.③The MCA Vm was in creasing with the effective therapy.Conclusion:The c hanges of Vm may be of help to find the area of ischemic stroke,to select the c linical therapeutic method and to evaluate the therapeutic effects.