CLINICAL RESEARCH ON TREATMENT FOR CHRONIC SEVERE HEPATITIS B WITH ENTECAVIR

[Objective] To probe of clinical research on treatment for chronic severe hepatitis B with Entecavir. [Methods] Selected 52 cases with severe chronic hepatitis B admitted to our hospital during October 2008-December 2009, patients were randomly divided into treatment group (27 cases) and control group (25 cases). Liver treatment was commonly used in the control group, besides the common treatment, the treatment group was given Entecavir. [Results] Compared with the control group, Entecavir treatment group significantly lowered the levels of TB after treatment, and significantly increased the total efficiency, reduced inefficiency, as well as induced a significant reduction in HBV-DNA level, there was a statistical significance (P﹤0.05). [Conclusion] Entecavir for treatment of chronic severe hepatitis B is the effective drug in clinical practice and should be widely applied.