Epidemiological analysis of 783 cases of lymphoma

OBJECTIVE The study aimed to investigate the epidemic pattern and clinical features of lymphoma by analyzing the epidemiological data among lymphoma patients in our hospital. METHODS Clinical data, including gender and age,pathological type, earliest affected site, and laboratory test results, of pathology lab-confirmed lymphoma patients treated in our hospital between January 1, 2002 and December 31, 2011 were collected, and the morbidity pattern, clinical features,and effectiveness of the treatments were analyzed. RESULTS Among the 783 lymphoma cases, the number of male patients was higher than that of female patients, resulting in an overall male to female ratio of 1.72 ︰ 1; age of the patients ranged from 9-87 years old, with an average age of 46 and median age of 43. Non-Hodgkin lymphoma(NHL) was the most common pathological type among the cases, with a NHL to Hodgkin lymphoma(HL) ratio of 5.21︰1. Among the 126 HL cases,44.44% were of mixed cellularity type and 38.10% were nodular sclerosis HL; most of the patients were at Stage Ⅲ Group A,accouting for 21.43% of the HL cases, and 84.92% of the onset involved lymph node lesion. Among the 657 NHL cases, the most prevalent pathological type was diffuse large B-cell lymphoma(38.10%); other common types included mucosa-associated lymphoid tissue lymphoma, follicular lymphoma, peripheral T-cell lymphoma, and anaplastic large cell lymphoma;most patients were at Stage III Group B, accounting for 16.29% of the NHL cases, and 43.22% of the onset involved lymph node lesion. The most common extranodal sites included the digestive system, Waldeyer-ring, nasal sinus, and nasal cavity.Levels of serum lactic acid dehydrogenase(LDH) and β2-microglobulin(β2-MG) were significantly higher in advanced lymphoma patients. CONCLUSION The number of lymphoma patients hospitalized in our hospital is on the rise. Clinical and pathological features of the patients are shown to be different from related domestic and international research results, and clinical features between HL and NHL were also distinct.