PTEN公司
癌症研究
癌变
胰腺癌
癌症
转移
细胞生长
旁侵犯
抑癌基因
细胞凋亡
生物
受体
抑制器
腺癌
内科学
医学
PI3K/AKT/mTOR通路
遗传学
作者
Jiangning Gu,Di Wang,Jiaqiang Zhang,Yi Zhu,Ying Li,Hao Chen,Minmin Shi,Xuelong Wang,Baiyong Shen,Xiaxing Deng,Qimin Zhan,Gang Wei,Chenghong Peng
出处
期刊:Cancer Letters
[Elsevier]
日期:2016-10-01
卷期号:380 (2): 434-441
被引量:50
标识
DOI:10.1016/j.canlet.2016.06.016
摘要
Nerve growth factors and their receptors have received an increasing attention in certain cancers since they play an important role in regulating tumorigenesis, biological process and metastasis. Here we aimed at characterizing a new function of one of the subtypes of growth factor receptors (GFR), GFRα2, in pancreatic cancer. In this study, we showed that GFRα2 was up-regulated in pancreatic adenocarcinoma and was positively correlated with tumor size and perineural invasion, which indicated that it may be associated with cell growth and apoptosis. Mechanically, we discovered that high GFRα2 expression level leads to PTEN inactivation via enhancing Mir-17-5p level.
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