In the paper, apart from the results of clinical application of biocompatible polymeric fixatives, are presented the detailed characteristics of physical and mechanical properties of polymeric rods, indicated prospects for development of the following generations of biocompatible polymeric fixatives, exhibiting not only high strength but therapeutic activity as well due to incorporation of different medicinal substances as components of the polymeric base composition. The authors present detailed description of the combined osteosynthesis methods on a basis of use of biocompatible polymeric fixatives according to the fracture localization, period of time elapsed since the moment of trauma etc., analyze the remote results of the treatment.