Isolation and identification of the chemical constituents from roots of Angelica sinensis(Oliv.)Diels

Objective To isolate and identify the chemical constituents from roots of Angelica sinensis(Oliv.)Diels.Methods Compounds were isolated by various kinds of column chromatography methods and preparative TLC,and their structures were identified by the physico-chemical characters and the spectral analysis.Results Thirteen compounds were isolated and their structures were identified as:3-butylphthalide(1),4-hydroxy-3-butylphthalide(2),2-methoxy-2-(4′-hydroxyphenyl)ethanol(3),ferulic acid(4),magnolol(5),baicalin(6),2″-O-(2″-methylbutyryl)-isoswertisin(7),harman(8),1-acetyl-β-carboline(9),flazine(10),α-spinasterol(11),isoimperaterin(12)and 3(R),8(S)-falcarindiol(13).Conclusions Compounds 3,7-8,11 are isolated from Angelica genus for the first time,and compound 5 is isolated from this plant for the first time.