Loss of Heterozygosity on 5q23.1-q23.2 in Esophageal Squamous Cell Carcinoma

To analyze microsatellite markers with high frequencies of loss of heterozygosity on 5q23.1 q23.2 in esophageal squmous cell carcinoma (ESCC). Polymerase chain reaction (PCR) based loss of heterozygosity(LOH) analysis was performed in 50 primary ESCC with six microsatellite markers. The frequencies of allelic loss of D5S471 and D5S592 were 47%and 41%, respectively. [Conclusion]There probably existed candidate tumor suppressor gene(s) around D5S592 and D5S471.