Role of Transient Receptor Potential Cation Channel 6 in Podocyte Injury

Recent studies have shown that transient receptor potential cation channel 6(TRPC6) expressed in podocytes,and located in slit diaphragm,it colocalized with nephrin,podocin and CD2AP,participating in signal transduction and maintaining podocytes normal construction and function.Mutations in TRPC6 cause autosomal dominant familial focal segmental glomerulosclerosis which is characterized by grade proteinuria and podocyte injury.In vitro studies,it also indicates that overexpression of TRPC6 leads to podocyte dysfunction,maybe through elevating calcium influx,suggesting that TRPC6 associates with the onset and development of proteinuria.This article will describe the role of TRPC6 in podocyte injury,maybe provide us the new targets for diagnosing and theraping renal disorders in the future.