Preventive and treatment of nontoxigenic Clostridium difficil to toxigenic Clostridium difficile infection of BALB/c mice

Objective To observe the prevention and treatment effect of nontoxigenic Clostridium difficile to protect BALB/c mice against intestinal infection caused by toxigenic Clostridium difficile.Methods Nontoxigenic Clostridium difficile was used before and after infection with toxigenic Clostridium difficile in BLAB/c mice.The mortality of mice,quantity of cytotoxin produced in cecal and histopathogencal destroy were observed.Results There were no bacterioprophylaxis using and nontoxigenic Clostridium difficile against infection by toxigenic Clostridium difficile,but the enterocolitis of the caecum after the mice was pre-infected with toxigenic Clostridium difficile.Conclusion The study confirms the protective effect and nontoxigenic Clostridium difficile treatment on BLAB/c mice pre-infected with toxinogenic Clostridium difficile.