Left ventricular function of ventricular remodeling in patients after acute myocardial infarction evaluated by quantitative tissue velocity imaging

Objective To investigate the clinical value of quantitative tissue velocity imaging (QTVI) for assessment of left ventricular (LV) remodeling and systolic and diastolic function after acute myocardial infarction in patients. Methods The segmental left ventricular wall motion velocity was measured in 22 normal subjects and 29 patients after acute myocardial infarction, and the peak velocity of LV regional myocardium during systole (V_S), early diastole (V_E) and atrial contraction (V_A). V_E/V_A ratio were also calculated. Mitral value peak flow velocities during early diastole (E) and atrial contraction (A), were also measured and E/A ratio was calculated. LV ejection fraction(EF), sphericity index (SI), LV end-systolic and end-diastolic volume (LVESVI and LVEDVI) were calculated The parameters were analyzed between the two groups. Results Expects at the base and middle segments of posterior inter ventricular septum, V_S of the segmental LV wall in infarcted group were significantly decreased (P0.01). V_E, V_A, V_E/V_A of the segmental LV wall in infarcted group were all significantly decreased (P0.05). The mean peak systolic velocity of the segmental LV wall correlated positively to LVEF and SI (r=0.79, 0.68 respectively, P0.01). The mean V_E/V_A ratio of segmental LV wall correlated positively to E/A ratio of mitral value flow (r=0.62, P0.01). SI, LVESVI and LVEDVI in infarcted group were significantly increased (P0.01). Conclusion QTVI is a rapid, comprehensive, and valuable method to quantitatively assess LV remodeling and systolic and diastolic function after acute myocardial infarction.