香叶基锗化
医学
结直肠癌
血管生成
他汀类
癌症
前列腺癌
癌症预防
炎症
疾病
人口
生物信息学
HMG-CoA还原酶
癌症研究
预酸化
免疫学
内科学
还原酶
生物
酶
环境卫生
生物化学
作者
Marie‐France Demierre,Peter Higgins,Stephen B. Gruber,Ernest T. Hawk,Scott M. Lippman
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2005-12-01
卷期号:5 (12): 930-942
被引量:726
摘要
Randomized controlled trials for preventing cardiovascular disease indicated that statins had provocative and unexpected benefits for reducing colorectal cancer and melanoma. These findings have led to the intensive study of statins in cancer prevention, including recent, large population-based studies showing statin-associated reductions in overall, colorectal and prostate cancer. Understanding the complex cellular effects (for example, on angiogenesis and inflammation) and the underlying molecular mechanisms of statins (for example, 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase-dependent processes that involve geranylgeranylation of Rho proteins, and HMG-CoA-independent processes that involve lymphocyte-function-associated antigen 1) will advance the development of molecularly targeted agents for preventing cancer. This understanding might also help the development of drugs for other ageing-related diseases with interrelated molecular pathways.
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