神经科学
光遗传学
人脑
运动皮层
髓鞘
运动前神经元活动
生物
皮质(解剖学)
心理学
中枢神经系统
刺激
作者
Elaine Gibson,David Purger,Christopher Mount,Andrea Goldstein,Grant L. Lin,L. D. H. Wood,Ingrid Inema,Sarah E. Miller,Gregor Bieri,J. Bradley Zuchero,Ben A. Barres,Pamelyn Woo,Hannes Vogel,Michelle Monje
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2014-05-02
卷期号:344 (6183)
被引量:1048
标识
DOI:10.1126/science.1252304
摘要
On-Demand Activity Oligodendroglia ensheath axons in the brain with myelin, which provides the insulation that speeds up transmission of neuronal electrical impulses. The process of myelination in the human brain goes on for decades, concurrent with all manner of brain development and cognitive activity. Gibson et al. (p. 10.1126/science.1252304 , published online 10 April; see the Perspective by Bechler and ffrench-Constant ) used optogenetics to study myelination in response to neural activity. Electrical activity in the motor cortex of the brain of awake mice led to proliferation and differentiation of oligodendrocytes and consequently increased myelination and alterations in motor response.
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