Recent Progress in Palladium-Catalyzed Asymmetric Hydrophos­phination

Asymmetric construction of P–C bonds is considered to be one of the most powerful methods for the preparation of chiral organophosphorus compounds. This review highlights recent progress in palladium-catalyzed asymmetric hydrophosphination reactions involving activated C=C bonds and diarylphosphines. The main catalytic systems employed for this protocol together with current substrate scope and mechanistic insights are described. 1 Introduction 2 Five-Membered CN/CP Palladacycle Catalyzed Protocols 3 PCP Pincer-Type Catalyst Based Protocols 4 NCN and PCN Pincers as Catalysts 5 Conclusion and Outlook