苯并呋喃
化学
薗头偶联反应
布氏锥虫
恶性疟原虫
酰化
立体化学
组合化学
双环分子
化学合成
有机化学
生物化学
体外
疟疾
催化作用
免疫学
钯
基因
生物
作者
Marion Thévenin,Sylviane Thoret,Philippe Grellier,Joëlle Dubois
标识
DOI:10.1016/j.bmc.2013.07.002
摘要
A series of polysubstituted benzofuran derivatives was easily and rapidly prepared using a tandem Sonogashira coupling/cyclization reaction. Subsequent acylation afforded a small library of 39 new compounds that were assayed in cellulo on Plasmodium falciparum and Trypanosoma brucei parasites. Some of them exhibited good inhibitory activity on T. brucei proliferation.
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