In vivo fluorescence imaging for Cu2+ in live mice by a new NIR fluorescent sensor

Modifying the BODIPY fluorophore with a 4-aminostyryl group forms a NIR fluorescent Cu2+ sensor with a large Stokes shift, high photostability and a high quantum yield. The in vivo Cu2+ fluorescence imaging in live mice was realized for the first time with this sensor, profiting from its reduced self-absorption and minor photobleaching.