凝聚
聚丙烯酸
乙二醇
伤口愈合
粘附
胶粘剂
材料科学
组织粘连
生物粘附
自愈水凝胶
单宁酸
化学
高分子化学
化学工程
生物医学工程
纳米技术
聚合物
复合材料
色谱法
有机化学
外科
医学
图层(电子)
工程类
作者
Lingshuang Wang,Lian Duan,Ga Liu,Jianfeng Sun,Mohammad‐Ali Shahbazi,Subhas C. Kundu,Rui L. Reis,Bo Xiao,Xiao Feng Yang
标识
DOI:10.1002/advs.202207352
摘要
Polyacrylic acid (PAA) and its derivatives are commonly used as essential matrices in wound dressings, but their weak wet adhesion restricts the clinical application. To address this issue, a PAA-based coacervate hydrogel with strong wet adhesion capability is fabricated through a facile mixture of PAA copolymers with isoprenyl oxy poly(ethylene glycol) ether and tannic acid (TA). The poly(ethylene glycol) segments on PAA prevent the electrostatic repulsion among the ionized carboxyl groups and absorbed TA to form coacervates. The absorbed TA provides solid adhesion to dry and wet substrates via multifarious interactions, which endows the coacervate with an adhesive strength to skin of 23.4 kPa and 70% adhesion underwater. This coacervate achieves desirable self-healing and extensible properties suitable for frequently moving joints. These investigations prove that the coacervate has strong antibacterial activity, facilitates fibroblast migration, and modulates M1/M2 polarization of macrophages. In vivo hemorrhage experiments further confirm that the coacervate dramatically shortens the hemostatic time from hundreds to tens of seconds. In addition, full-thickness skin defect experiments demonstrate that the coacervate achieves the best therapeutic effect by significantly promoting collagen deposition, angiogenesis, and epithelialization. These results demonstrate that a PAA-based coacervate hydrogel is a promising wound dressing for medical translation.
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