Metal‐Based Nanocatalysts: Exploring New Frontiers in Antibacterial Therapy

Abstract Antimicrobial resistance (AMR) represents a grave and escalating threat to global public health, as the efficacy of traditional antibiotics is progressively compromised by the rapid evolution of pathogens and the pervasive dissemination of resistance genes. In response, metal‐based nanocatalysts have emerged as promising alternatives, exhibiting substantial potential in antibacterial therapies. Here, a systematic and comprehensive analysis of recent advancements is provided in catalytic antibacterial strategies employing metal‐based nanomaterials. It begins by delineating the pressing challenges posed by AMR and introduces the development of nanocatalysts as innovative solutions to address the limitations of conventional treatments. The various types of catalytic antibacterial mechanisms are systematically categorized and elucidated. Subsequently, the classification of metal‐based nanocatalysts is explored, discussing their composition, active sites, catalytic properties, and antibacterial applications in detail. Strategies for the rational design and synthesis of nanomaterials with enhanced activity are also highlighted. Furthermore, the implementation of these nanocatalysts in diverse infection scenarios is discussed, with the aim of advancing the development of precise and sustainable anti‐infective technologies. This is concluded by identifying current challenges and proposing future directions for the integration of nanocatalysts into clinical antibacterial therapies.