Paraventricular nucleus neurons: important regulators of respiratory movement in mice with chronic intermittent hypoxia

A direct relationship exists between the PVN and preBötC. CIH increased c-Fos expression in respiratory-related nuclei, including the PVN. Modulating the PVN activity impacts MV by adjusting the RF; without influencing arterial blood gas levels. The PVN is probably involved in respiratory control via the PVN-preBötC circuit.