Case series of patients with acute and chronic urticaria after COVID-19 vaccination

COVID-19 vaccinations have been associated with various sequelae including skin eruptions and allergic reactions.1 Literature suggests a possible association between COVID-19 infection or COVID-19 vaccination and spontaneous urticaria, both acute and chronic forms.2,3 Spontaneous urticaria is characterized by recurrent hives with or without angioedema. If symptoms last 6 or more weeks, urticaria is classified as chronic. During the spring of 2022, allergy providers at a large health system in the upper Midwest noted patients presenting with spontaneous urticaria with onset within weeks after receiving their first COVID-19 vaccination booster.