胆绿素
神经保护
胆绿素还原酶
胆红素
神经科学
化学
医学
生物化学
内科学
生物
酶
血红素加氧酶
血红素
作者
Bindu D. Paul,Andrew A. Pieper
出处
期刊:Biomolecules
[MDPI AG]
日期:2024-01-28
卷期号:14 (2): 155-155
摘要
Biliverdin reductase-A (BVRA) is a multi-functional enzyme with a multitude of important roles in physiologic redox homeostasis. Classically, BVRA is well known for converting the heme metabolite biliverdin to bilirubin, which is a potent antioxidant in both the periphery and the brain. However, BVRA additionally participates in many neuroprotective signaling cascades in the brain that preserve cognition. Here, we review the neuroprotective roles of BVRA and bilirubin in the brain, which together constitute a BVRA/bilirubin axis that influences healthy aging and cognitive function.
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