化学
芳基
烷基
催化作用
药物化学
光催化
有机化学
光催化
作者
Jian-Hong Fan,Jun Yuan,Pengfei Xia,Jiao Zhou,Long‐Jin Zhong,Pengfei Huang,Yu Liu,Kewen Tang,Jin‐Heng Li
标识
DOI:10.1021/acs.orglett.4c00333
摘要
A visible-light-induced radical alkylarylation of N-aryl bicyclobutyl amides with α-carbonyl alkyl bromides for the synthesis of functionalized 3-spirocyclobutyl oxindoles is described in which β-selective radical addition of the alkyl radical to N-aryl bicyclobutyl amides forms a key radical intermediate followed by interception with intrinsic arene functional group. This approach can be applicable to a wide range of α-carbonyl alkyl bromides, including primary, secondary, and tertiary α-bromoalkyl esters, ketones, nitriles, and nitro compounds.
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