卵巢
NAD+激酶
CD38
生物
卵泡期
生育率
转录组
男科
基因表达
基因
内科学
细胞生物学
内分泌学
医学
遗传学
干细胞
酶
川地34
环境卫生
生物化学
人口
作者
Qingling Yang,Wenhui Chen,Luping Cong,Mengchen Wang,Hui Li,Huan Wang,Xiaoyan Luo,Jing Zhu,Xinxin Zeng,Zhenye Zhu,Yining Xu,M. Lei,Yanqing Zhao,Chenlu Wei,Yingpu Sun
出处
期刊:Nature Aging
日期:2023-12-21
卷期号:4 (1): 110-128
被引量:10
标识
DOI:10.1038/s43587-023-00532-9
摘要
Abstract The ovary ages earlier than most other tissues, yet the underlying mechanisms remain elusive. Here a comprehensive analysis of transcriptomic landscapes in different organs in young and middle-aged mice revealed that the ovaries showed earlier expression of age-associated genes, identifying increased NADase CD38 expression and decreased NAD + levels in the ovary of middle-aged mice. Bulk and single-cell RNA sequencing revealed that CD38 deletion mitigated ovarian aging, preserving fertility and follicle reserve in aged mice by countering age-related gene expression changes and intercellular communication alterations. Mechanistically, the earlier onset of inflammation induced higher expression levels of CD38 and decreased NAD + levels in the ovary, thereby accelerating ovarian aging. Consistently, pharmacological inhibition of CD38 enhanced fertility in middle-aged mice. Our findings revealed the mechanisms underlying the earlier aging of the ovary relative to other organs, providing a potential therapeutic target for ameliorating age-related female infertility.
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