活动记录
蒙特利尔认知评估
睡眠(系统调用)
听力学
睡眠剥夺对认知功能的影响
认知障碍
认知
医学
痴呆
心理学
内科学
昼夜节律
精神科
计算机科学
操作系统
疾病
作者
Nárlon Cássio Boa Sorte Silva,Ryan S. Falck,Pak Hei Chan,Daria Tai,Daniel Backhouse,Ryan G Stein,Teresa Liu‐Ambrose
标识
DOI:10.1016/j.exger.2022.111923
摘要
We investigated whether device-measured sleep parameters are associated with cortical thickness in older adults with probable mild cognitive impairment (MCI). We performed a cross-sectional, exploratory analysis of sleep and structural MRI data. Sleep data were collected with MotionWatch8© actigraphy over 7 days. We computed average and variability for sleep duration, sleep efficiency, and fragmentation index. T1-weighted MRI scans were used to measure cortical thickness in FreeSurfer. We employed surface-based analysis to determine the association between sleep measures and cortical thickness, adjusting for age, sex, Montreal Cognitive Assessment (MoCA) score, and sleep medication use. Our sample included 113 participants (age = 73.1 [5.7], female = 72 [63.7 %]). Higher fragmentation index variability predicted lower cortical thickness in the left superior frontal gyrus (cluster size = 970.9 mm2, cluster-wise p = 0.017, cortical thickness range = 2.1 mm2 to 3.0 mm2), adjusting for age, sex, MoCA, and sleep medication. Our results suggest that higher variability in sleep fragmentation, an indicator of irregular sleep pattern, is linked to lower cortical thickness. Future longitudinal studies are needed to determine the directionality of these associations.
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