Tailoring the austenite characteristics via dual nanoparticles to synergistically optimize the strength-ductility in cold rolled medium Mn steel

It is desirable to develop a free radical generator that is neither dependent on hydrogen peroxide nor external stimuli-triggered to achieve effective tumor treatment. Herein, the free radical generator MNPs-mCPBA was constructed with Zn0.4Co0.6Fe2O4@Zn0.4Mn0.6Fe2O4 nanoparticles (MNPs) and 3-chloroperbenzoic acid (mCPBA). We believe that the iron (II) on the surface of MNPs-mCPBA maybe represent high reactive activity and promote the generation of a large number of organic free radicals (C6H4ClCOOO⋅) in an acidic tumor microenvironment, which realizes the acid-dependent tumor treatment strategy independent on the H2O2 level in tumors. In addition, the generated organic free radicals (C6H4ClCOOO⋅) effectively induced immunogenic cell death (ICD) and increased T cell infiltration. Under the synergetic treatment with an anti-PD-L1 antibody (α-PD-L1), a favorable anti-tumor effect was achieved.