褪黑素
检出限
介电谱
电化学气体传感器
电化学
化学计量学
剥脱关节
相对标准差
材料科学
化学
分析化学(期刊)
纳米技术
色谱法
电极
生物
物理化学
神经科学
石墨烯
作者
Rut Martínez‐Moro,María del Pozo,Luís Vázquez,José Á. Martín‐Gago,María Dolores Petit‐Domínguez,Elena Casero,Carmen Quintana
标识
DOI:10.1038/s41598-023-37401-9
摘要
We present the development of an electrochemical sensor towards melatonin determination based on the synergistic effect between MoS2 nanosheets and cucurbit[8]uril. For the sensor construction cucurbit[8]uril suspensions were prepared in water, and MoS2 nanosheets were obtained by liquid exfoliation in ethanol:water. The sensing platform was topographically characterized by Atomic Force Microscopy. Electrochemical Impedance Spectroscopy experiments allowed us to study the charge transfer process during melatonin oxidation. Moreover, stoichiometry of the resulting complex has also been determined. After the optimization of the sensor construction and the experimental variables involved in the Differential Pulse Voltammetric response of melatonin, detection limit of 3.80 × 10-7 M, relative errors minor than 3.8% and relative standard deviation lower than 4.4% were obtained. The proposed sensor has been successfully applied to melatonin determination in pharmaceutical and biological samples as human urine and serum, with very good recoveries ranging from 90 to 102%.
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