高尿酸血症
医学
超重
优势比
内科学
体质指数
尿酸
痛风
代谢综合征
置信区间
肥胖
糖尿病
逻辑回归
胃肠病学
内分泌学
作者
Maria de Fátima Haueisen Sander Diniz,Huiyun Du,Aline Isabel Rodrigues Galvão,Rosa Weiss Telles,María Inês Schmidt,Bruce Bartholow Duncan,Isabela Judith Martins Benseñor,Antônio Luiz Pinho Ribeiro,Pedro Guatimosim Vidigal,Sandhi Maria Barreto
标识
DOI:10.1016/j.diabres.2022.110046
摘要
To investigate whether serum uric acid (SUA) levels and hyperuricemia can be predictive biomarkers of incident metabolic syndrome(MS) among different body mass index(BMI) categories, and to investigate SUA cutoffs that best discriminate individuals with incident MS.We analyzed 7,789 participants without MS at baseline of ELSA-Brasil study. Logistic regression models were performed to evaluate associations between incident MS and SUA levels/hyperuricemia, expressed by odds ratios(ORs) and confidence intervals(95 % CI).We found 1,646 incident MS cases after a median follow-up of 3.8[3.5-4.1] years. Incident MS was present among 8.3 % (n = 290) of participants with normal weight, 28.3 % (n = 850) with overweight, 39.8 % (n = 506) with obesity. Among incident MS participants of total sample, 33.0 % had hyperuricemia [SUA > 6.0 mg/dL (356.9 μmol/L)]. After all adjustments, SUA was independently prognostic of incident MS: for each 1 mg/dL increase in SUA the odds of incident MS were 45 % higher (OR1.45[CI95 %1.34-1.55 p <.01]). Associations were found for those presenting normal weight, overweight and obesity (OR1.43[CI95 %1.31-1.57 p <.01; OR1.22[CI95 %1.13-1.32 p <.01]; and OR1.16[CI95 %1.04-1.29 p <.05]) respectively. Hyperuricemia was independently associated with incident MS (OR1.88[CI95 %1.49-0.2.36 p <.01]). The SUA cut point level maximizing sensitivity and specificity in the discrimination of incident MS was 5.0 mg/dL.SUA level is an independent predictive biomarker of incident MS at all BMI categories.
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