子宫腺肌病
活产
医学
胚胎移植
产科
怀孕
流产
妇科
回顾性队列研究
子宫
人口
子宫内膜异位症
外科
生物
内科学
环境卫生
遗传学
作者
E. Shirin Dason,Madalina Maxim,Alexander Hartman,Qixuan Li,Salina Kanji,Tiantian Li,Charis Ng,Ella Huszti,Mara Sobel,Crystal Chan
标识
DOI:10.1016/j.fertnstert.2022.12.021
摘要
To use the Morphological Uterus Sonographic Assessment (MUSA) criteria to evaluate the impact of adenomyosis on the live birth rate after donor egg embryo transfer.Retrospective cohort study.Tertiary fertility care center.A total of 100 patients who received 223 donor embryo transfers from January 2014-2020. All patients underwent ultrasound before their first transfer.None.Our study was powered (80%) to assess the primary outcome of live birth rate; the secondary outcomes included the clinical pregnancy, biochemical pregnancy, and miscarriage rates.Only 22 of 100 patients were diagnosed with adenomyosis on the original ultrasound report. When the MUSA criteria were applied, 76 patients had at least 1 possible ultrasonographic feature of adenomyosis; all 76 patients had an interrupted junctional zone. The second most common feature of adenomyosis was a globular and/or enlarged uterus (89.4%). Adjusted modeling demonstrated that a single ultrasound feature, 2 or more features, specific features, or the location of features did not affect the live birth outcome. A per-centimeter increase in the diameter of focal lesions was significantly associated with a decrease in the odds of live birth by the factor of 0.91.To our knowledge, our study is the first to characterize adenomyosis using the MUSA criteria in the donor oocyte population. Overall, our data were reassuring in that the ultrasonographic features of adenomyosis may not impact reproductive outcomes. However, we identified that the location and size of focal lesions may be important and should be studied further.
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