Dynamic changes of inulin utilization associated with longitudinal development of gut microbiota

菊粉 蔷薇花 肠道菌群 发酵 益生元 生物 微生物代谢 双歧杆菌 微生物学 果糖 磷酸戊糖途径 食品科学 乳酸菌 新陈代谢 细菌 生物化学 遗传学 糖酵解
作者
Nana Chen,Yalin Liu,Siyu Wei,Xin Zong,Zhou Guiyuan,Zeqing Lu,Fengqin Wang,Yizhen Wang,Mingliang Jin
出处
期刊:International Journal of Biological Macromolecules [Elsevier]
卷期号:229: 952-963 被引量:1
标识
DOI:10.1016/j.ijbiomac.2022.12.318
摘要

Inulin is a typical kind of fermentable polysaccharide and has emerged as a promising dietary supplement due to its multiple health-promoting effects. This study aimed to unveil the dynamic change pattern of inulin utilizability as a fermentation substrate during gut microbiota development and illuminate its potential association with gut microbiota in Chinese Jinhua native pig models via longitudinal analyses. Herein, fresh feces were collected at one week pre- and post-weaning as well as 3rd month post-weaning, respectively. Targeted metabolomics and in vitro simulated fermentation revealed increasing concentrations of fecal short-chain fatty acids (SCFAs) and elevating utilizability of inulin as a fermentation substrate. Microbiomic analyses demonstrated the conspicuous longitudinal alteration in gut microbial composition and a significant rise in microbial community diversity during gut microbiota development. Furthermore, gut microbial functional analyses showed a remarkable increase in the relative abundances of carbohydrate metabolism pathways, including pentose phosphate pathway, galactose metabolism pathway, butanoate metabolism pathway as well as fructose and mannose metabolism pathway. Notably, relative abundances of bacterial genera Bifidobacterium, Roseburia, Faecalibacterium and Enterococcus displayed significantly positive correlations with the production of microbial fermentation-derived SCFAs. Collectively, these findings offer novel insights into understanding inulin utilizability variations from the perspective of gut microbiota development.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
陌上完成签到,获得积分20
1秒前
张晓媛发布了新的文献求助10
1秒前
1秒前
富士山下完成签到,获得积分10
1秒前
2秒前
英姑应助小M采纳,获得10
3秒前
PL发布了新的文献求助10
3秒前
小王王完成签到,获得积分20
4秒前
4秒前
科研通AI2S应助李大壮采纳,获得30
5秒前
QZY2021完成签到,获得积分10
5秒前
5秒前
7秒前
桐桐应助wodetaiyangLLL采纳,获得10
8秒前
陌上发布了新的文献求助20
9秒前
科研靓仔完成签到,获得积分10
9秒前
ww完成签到,获得积分10
10秒前
王欣雪发布了新的文献求助10
10秒前
CipherSage应助LSM采纳,获得10
10秒前
10秒前
graphzeng发布了新的文献求助10
10秒前
可爱的函函应助张晓媛采纳,获得10
12秒前
12秒前
14秒前
Kenny-Liliy完成签到 ,获得积分0
14秒前
cctv18应助温柔的刀采纳,获得10
15秒前
脸就是黑啊完成签到,获得积分10
15秒前
斯文蓉完成签到,获得积分10
15秒前
16秒前
小M发布了新的文献求助10
16秒前
18秒前
明天就交稿完成签到,获得积分10
19秒前
冰凉完成签到,获得积分10
20秒前
木头人应助梓桐采纳,获得20
22秒前
LSM发布了新的文献求助10
22秒前
24秒前
酷波er应助llyric采纳,获得10
24秒前
25秒前
柯一一应助mmmmmm采纳,获得10
26秒前
26秒前
高分求助中
Sraffa and applied economics: are there classical supply curves? 1000
Heun’s Differential Equations 600
《Fundamentals of Power Supply Design》Robert A. Mammano 510
谁能看见前面有梦可想 500
Wind Effects on Structures: An Introduction to Wind Engineering and Wind Forces in Engineering (2nd Edition) 300
Against the Grain: The Vayda Tradition in Human Ecology and Ecological Anthropology 300
High Wire: How China Regulates Big Tech and Governs Its Economy 260
热门求助领域 (近24小时)
化学 材料科学 医学 生物 有机化学 工程类 生物化学 纳米技术 物理 内科学 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 电极 光电子学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 2248687
求助须知:如何正确求助?哪些是违规求助? 1898034
关于积分的说明 4732416
捐赠科研通 1687121
什么是DOI,文献DOI怎么找? 856135
版权声明 545086
科研通“疑难数据库(出版商)”最低求助积分说明 453073