光热治疗
牛血清白蛋白
光动力疗法
单线态氧
材料科学
生物医学中的光声成像
黑色素瘤
荧光
化学
纳米技术
癌症研究
医学
生物化学
氧气
光学
有机化学
物理
作者
Shuo Li,Guoyang Zhang,Yanghan Peng,Peiyu Chen,Ji‐Guang Li,Xuefei Wang,Zhuo Wang
标识
DOI:10.1002/adhm.202300327
摘要
Tyrosinase (TYR) is an important biomarker of melanoma. The exploration of fluorescent pr-obes-based composites is beneficial to build an integrative platform for the diagnosis and treatment of melanoma. Herein, a multifunctional nanocomposite IOBOH@BSA activated by TYR is developed for selective imaging and ablation of melanoma. The chemical structure of IOBOH enables the fluorescence (FL) imaging activated by TYR, photoacoustic (PA) imaging, and photodynamic-photothermal activity by regulating the balance between radiative decay and non-radiative decay. IOBOH combined with bovine serum albumin (IOBOH@BSA) presents the response to TYR and realizes FL imaging with mitochondria-targeting in melanoma. Moreover, IOBOH@BSA shows excellent photothermal ability and is applied for PA imaging. After IOBOH@BSA is activated by TYR, the singlet oxygen generation increases obviously. IOBOH@BSA can realize TYR-activated imaging and photodynamic-photothermal therapy of melanoma. The development of TYR-activated multifunctional nanocomposites promotes the precise imaging and improves the therapeutic effect of melanoma.
科研通智能强力驱动
Strongly Powered by AbleSci AI