光动力疗法
光敏剂
谷胱甘肽
姜黄素
两亲性
化学
药理学
下调和上调
组合化学
癌症研究
生物化学
酶
聚合物
医学
光化学
有机化学
共聚物
基因
作者
J. F. Wu,Jingjing Shang,Jing An,Wenlong Chen,Gaobo Hong,Haoran Hou,Zheng Wei,Fengling Song,Xiaojun Peng
标识
DOI:10.1002/cbic.202300323
摘要
Abstract Photodynamic therapy (PDT) is one common ROS‐generating therapeutic method with high tumor selectivity and low side effects. But the GSH‐upregulation often alleviates its therapeutic efficiency. Here, we proposed a new strategy of jointly depleting GSH to enhance the therapeutic effect of PDT by preparing a nanomicelle by self‐assembly method from GSH‐activated photosensitizer DMT, curcumin, and amphiphilic polymer TPGS.
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