化学
废止
腈
组合化学
有机化学
级联
氯化物
催化作用
色谱法
作者
Byung Jun Park,Jiansheng Yang,Sung‐Gon Kim
标识
DOI:10.1021/acs.joc.3c00524
摘要
A novel and streamlined approach to synthesizing benzotriazepin-1-ones has been developed through a hexafluoroisopropanol-promoted decarboxylative cascade reaction between isatoic anhydrides and hydrazonoyl chloride. The [4 + 3] annulation of hexafluoroisopropyl 2-aminobenzoates with nitrile imines, generated in situ, is a key feature of this innovative reaction. This approach has offered a simple and efficient method for synthesizing a broad range of structurally intricate and highly functional benzotriazepinones.
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