苯并咪唑
细胞毒性T细胞
奥西多尔
细胞凋亡
化学
微管蛋白
细胞毒性
组合化学
聚合
立体化学
微管
生物化学
细胞生物学
生物
体外
有机化学
催化作用
聚合物
作者
Akash P. Sakla,Mohd Rabi Bazaz,Ashutosh Mahale,Pravesh Sharma,Durgesh Gurukkala Valapil,Onkar P. Kulkarni,Manoj P. Dandekar,Nagula Shankaraiah
标识
DOI:10.1002/cmdc.202400052
摘要
A series of spirocyclopropyl oxindoles with benzimidazole substitutions was synthesized and tested for their cytotoxicity against selected human cancer cells. Most of the molecules exhibited significant antiproliferative activity with compound 12p being the most potent. It exhibited significant cytotoxicity against MCF‐7 breast cancer cells (IC50 value 3.14 ± 0.50 µM), evidenced by the decrease in viable cells and increased apoptotic features during phase contrast microscopy, AO/EB, DAPI and DCFDA staining studies. Compound 12p also inhibited cell migration in wound healing assay. Anticancer potential of 12p was proved by the inhibition of tubulin polymerization with IC50 of 5.64 ± 0.15 µM. These results imply the potential of benzimidazole substituted spirocyclopropyl oxindoles, notably 12p, as cytotoxic agent for the treatment of breast cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI