光热治疗
材料科学
光热效应
高尔基体
内质网
纳米技术
生物物理学
癌症
细胞凋亡
癌细胞
细胞生物学
化学
生物
生物化学
遗传学
作者
Mingwan Shi,Zhongliang Fu,Wei Pan,Kaiye Wang,Xiaohan Liu,Na Li,Bo Tang
标识
DOI:10.1002/adhm.202303749
摘要
The Golgi apparatus (GA) is central in shuttling proteins from the endoplasmic reticulum to different cellular areas. Therefore, targeting the GA to precisely destroy its proteins through local heat could induce apoptosis, offering a potential avenue for effective cancer therapy. Herein, a GA-targeted photothermal agent based on protein anchoring is introduced for enhanced photothermal therapy of tumor through the modification of near-infrared molecular dye with maleimide derivative and benzene sulfonamide. The photothermal agent can actively target the GA and covalently anchor to its sulfhydryl proteins, thereby increasing its retention within the GA. Under laser irradiation, the heat generated by the photothermal agent efficiently disrupts sulfhydryl proteins in situ, leading to GA dysfunction and ultimately inducing cell apoptosis. In vivo experiments demonstrate that the photothermal agent can precisely treat tumors and significantly reduce side effects.
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