Stereodivergent Synthesis of Chiral Spiropyrazolones through Pd-Catalyzed Asymmetric Sequential Hydroalkylation of 1,3-Enynes: Unusual Solvent Effect on the Enantioselectivity

Chiral spiropyrazolones were constructed for the first time through Pd-catalyzed asymmetric sequential hydroalkylation of 1,3-enynes. Through substrate control (by exchanging the position of double bond and triple bond of 1,3-enyne...