变形
脚手架
细胞外基质
计算机科学
3D打印
3d打印
生物医学工程
植入
纳米技术
材料科学
工程类
化学
外科
医学
人工智能
复合材料
生物化学
作者
Guiwen Qu,Jinjian Huang,Guosheng Gu,Zongan Li,Xiuwen Wu,Jianan Ren
出处
期刊:International Journal of bioprinting
[Whioce Publishing Pte Ltd.]
日期:2023-05-30
卷期号:9 (5): 764-764
被引量:6
摘要
Biomedical implants have recently shown excellent application potential in tissue repair and replacement. Applying three-dimensional (3D) printing to implant scaffold fabrication can help to address individual needs more precisely. Fourdimensional (4D) printing emerges rapidly based on the development of shaperesponsive materials and design methods, which makes the production of dynamic functional implants possible. Smart implants can be pre-designed to respond to endogenous or exogenous stimuli and perform seamless integration with regular/ irregular tissue defects, defect-luminal organs, or curved structures via programmed shape morphing. At the same time, they offer great advantages in minimally invasive surgery due to the small-to-large volume transition. In addition, 4D-printed cellular scaffolds can generate extracellular matrix (ECM)-mimetic structures that interact with the contacting cells, expanding the possible sources of tissue/organ grafts and substitutes. This review summarizes the typical technologies and materials of 4D-printed scaffolds, and the programming designs and applications of these scaffolds are further highlighted. Finally, we propose the prospects and outlook of 4D-printed shape-morphing implants.
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