治疗方式
模式
精密医学
细胞疗法
计算机科学
再生医学
风险分析(工程)
生化工程
干细胞
医学
工程类
生物
病理
社会科学
社会学
遗传学
物理疗法
作者
Yixin Wang,Zhaoting Li,Fanyi Mo,Ting‐Jing Chen‐Mayfield,Aryan Saini,Afton Martin LaMere,Quanyin Hu
摘要
Cell-based therapy holds great potential to address unmet medical needs and revolutionize the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell therapy and stem cell transplantation that have achieved great success clinically. Nevertheless, natural cells are often restricted by their unsatisfactory in vivo trafficking and lack of therapeutic payloads. Chemical engineering offers a cost-effective, easy-to-implement engineering tool that allows for strengthening the inherent favorable features of cells and confers them new functionalities. Moreover, in accordance with the trend of precision medicine, leveraging chemical engineering tools to tailor cells to accommodate patients individual needs has become important for the development of cell-based treatment modalities. This review presents a comprehensive summary of the currently available chemically engineered tools, introduces their application in advanced diagnosis and precision therapy, and discusses the current challenges and future opportunities.
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