终纹
核心
下丘脑
神经科学
去神经支配
医学
交感神经切除术
神经病理性疼痛
内分泌学
麻醉
生物
内科学
精神科
作者
Shoumeng Han,Xin Chen,Li Ma,Xin Zeng,Ying Wang,Tingting Xie,Fancan Wu,Kun Song,Kenji Hashimoto,Hanbing Wang,Long Wang
标识
DOI:10.1007/s12264-025-01454-9
摘要
Abstract Neuropathic pain is a chronic condition caused by damage or dysfunction in the nervous system. While the spleen may influence neuropathic pain, its role has been poorly understood. This study demonstrates that the spleen plays a crucial role in regulating neuropathic pain through the bed nucleus of the stria terminalis (BNST) - paraventricular nucleus of the hypothalamus (PVN) neural circuit in a chronic constriction injury (CCI) mouse model. Splenectomy, splenic denervation, or splenic sympathectomy significantly increased the mechanical withdrawal threshold (MWT) and reduced macrophage infiltration in the dorsal root ganglia (DRG) of CCI mice. Pseudorabies virus injections into the spleen revealed connections to the BNST and PVN in the brain. Chemogenetic inhibition of the BNST-PVN circuit increased macrophage infiltration in the DRG and decreased the MWT; these effects were reversed by splenectomy, splenic denervation, or sympathectomy. These findings underscore the critical role of the spleen, regulated by the BNST-PVN circuit, in neuropathic pain.
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